ISS Expedition 14 was a manned mission to the International Space Station (ISS) conducted by NASA, the space agency of the United States, between April and October 2007. This expedition marked the beginning of the 13th long-duration increment crew on board the ISS. The crew comprised of Commander Sergei Vilkhu and Flight Engineer Nicholas Patrick from the Russian Federal Space Agency (Roscosmos), along with NASA's Flight Engineers Michael Lopez-Alegria and Sunita Williams, who served as the mission's first female Expedition Commander.During their stay aboard the ISS, the crew conducted numerous scientific research experiments, including microgravity studies on plant growth, human health, materials science, and Earth observations. They also performed several spacewalks for maintenance and upgrades to the station. The mission ended with the successful landing of Lopez-Alegria and Vilkhu in Kazakhstan on October 8, 2007, followed by Williams and Patrick's return to Earth on December 19, 2007, aboard Space Shuttle Discovery during STS-126.ISS Expedition 14 was a crucial part of the ongoing international cooperation in space exploration and marked significant steps forward in scientific research conducted in microgravity conditions. It paved the way for future long-duration missions on the ISS, including the upcoming Artemis program that aims to return humans to the Moon and prepare for eventual human missions to Mars.